Endocrine Abstracts

Background: The role of trivalent chromium (Cr3+) in improving glucose tolerance, and decreasing insulin resistance is well documented in animals and humans, however supplementation studies gave inconsistent results. Increased urinary excretion of chromium has been reported in type 2 diabetes mellitus (DM). It was not known whether this renal wasting had preceded DM, or was caused by it.Aim: Our aim was to investigate the relationship between ...

Background: Obesity, and metabolic syndrome (MS) are highly prevalent in Saudi Arabia, increasing the risk for type 2 diabetes (T2DM), and cardiovascular disease (CVD). Oligonol produced from lychee fruit polyphenols (LFP) has been reported to reduce visceral obesity, and ameliorate MS in Japanese subject.Aim: To investigate the effect of oligonol supplementation on MS risk factors in overweight and obese Saudi females.Subjects and...

Background: Fibroblast growth factor 19 (FGF19) is an enterokine derived from the ileum, and synthesized in response to release of bile acids following food ingestion. It was proposed to be an important regulator of the postprandial adaptive metabolic response. by stimulating glycogen and protein synthesis in the liver, and down regulating glucose production after a meal. There is limited research investigating the association between FG-19 and metabolic dysregulation in overw...

Introduction: Prevalence of obesity is increasing globally and in Saudi Arabia in particular. Obesity is associated with increased risk of diabetes and cardiovascular diseases. Therefore, studies to control obesity and its effect on health are important. Chitosan has been recommended as a suitable functional supplement for controlling obesity; and consequently; its associated complications. However, results were inconclusive.Aim: To investigate the effec...

Background: Different management modalities are used to control hyperglycaemia associated with type 2 diabetes (T2DM). Research has indicated an association of single or combined insulin therapy with increased cardiovascular events. Metabolic syndrome (MS), as well as increased levels of C-reactive protein (CRP), and gamma glutamyl transferase (GGT) are also associated with increased CVD risk.Aim: To study the relationship between management modality, gl...